This paper proposes an approach to the differentiated analysis of the temperature characteristics of exposed human dura mater and cerebral cortex within the operational window when intracerebral tumors are being removed. The key features of the method are the following: Taking into account the complex shape of the regions to be analyzed, extensive automation of batch processing of the IR thermal maps, operation with sizable samples (more than forty patients), and the use of rigorous statistical estimates. The central problem of using the technique developed here is how to analyze the data on the dynamics of thermal patterns in response to a cold test.