This article presents one of the approaches to the optimization of modern information and measurement system in unmanned vehicles. The development of unmanned aircraft vehicles (UAV) and unmanned aircraft system (UAS) models has seen a great increase in popularity recently. The existing research on unmanned aviation is innovative and it is progressing fast. The developments change their structure and form dramatically and improve the hardware and software components of various control and aiming systems (AS) while extending the list of utilities for them that are necessary for the fulfillment of the key control goals. Usually, the main blocks of multiloop AS components comprise information, measurement, and control systems (IMCS) that are also included in the automated control system (ACS) of the aircraft. It is often necessary to get an objective assessment of the technical level of such systems, especially at the early design stages, and analyze the preparation for the control decision making. Therefore, the suggested approach is based on the combined use of simulation modeling algorithms, and it stipulates a structure-and-parameter optimization of components within the IMCS blocks of the automated control system for unmanned aircrafts.